There are many solutions for this challenge. Here is one way that may work for you “out-of-the-box” (uses GP functionality without an add-ons or customizations):
Use the unit-of-measure schedule and price list functions to limit sales entry to particular units-of-measure. For instance, setup a unit-of-measure of Case12 and Case15 which are 12 each and 15 each respectively. Set the prices at these unit-of-measures only and do not allow overrides of prices.
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